Ambrose was in the Newcastle side the last time the clubs met, back in April 2005, and the only survivors from that matchday squad are Shola Ameobi, Steven Taylor and Steve Harper.
The 25-year-old said: "It's all changed, really. Shola's obviously still there, as is Steven Taylor. It would be good to see him stay there – he's Newcastle through and through.
"I'd have liked to put one past Steve Harper, but it wasn't to be!
"Hopefully we can come up to St James's Park and put in a good performance."