From what I've seen. Wilson is finished and should not be coming on and Osula wont make it, although, unlike Wilson, he can run around, even if he's not sure where he is running.
Personally think he has more chance as a wide forward than a striker.
Both are not good enough to stand in or play with Isak. But, I trust Howe and team to make the call on both, especially on Wilson, who should be offered to Ipswich as part of a Delap deal.