I really do think you've got a great chance of getting something.
Fabregas and Nasri a) not playing and b) about to leave hence some unhappiness in the squad is likely; Diaby and Wilshere out, RVP and Vermaelen need fitness tests. You're at home, opening day of the season. While I don't think there'll be loads of pressure on you as such, I'd go as far as to say it'd be a failure not to get something from this game given the circumstances.
While people may have seen the fixture list and thought, sigh, unlucky start, I think you should relish the chance to get a top 4 side (from last season) out the way in this particular set of circumstances. Yes you've had trouble yourselves, but get right at them and you could even win.