Yup, the subs will take place although it seems that the process is taking longer than usual. Manual subs is an option in the CL as the matches are played over 2 matchdays.
So many teams resting their players, it's hard to figure out who will start regularly. Including subs, I only have 9 players who played some part in matches. Courtois (GK!!!), Maggio, Sneijder, Krasic, Cavani all didn't start. Newcastle not taking the competition as seriously as other teams?